Lowering blood pressure and maintaining blood sugar control is absolutely necessary to slow the progression of diabetic nephropathy. Some medicines called angiotensin-converting enzyme (ACE) inhibitors can help slow down the progression of kidney damage. Although ACE inhibitors — including ramipril(Altace), quinapril (Accupril), and lisinopril (Prinivil, Zestril) — are usually used to treat high blood pressure and other medical problems, they are often given to people with diabetes to prevent complications, even if their blood pressure is normal.

If a person has side effects from taking ACE inhibitors, another class of drugs called angiotensin receptor blockers (ARBs) can often be given instead.

If not treated, the kidneys will continue to fail and larger amounts of proteins can be detected in the urine. Advanced kidney failure requires treatment with dialysis or a kidney transplant.